Pyriproxyfen 是昆虫生长调节剂，具有杀虫的作用， 属保幼激素类似物。

Pyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.

Zebrafish male adults were acutely exposed to 0.001, 0.01 and 0.1 μg/mL pyriproxyfen for 16 h. Mitochondrial respiration of brain tissues was assessed. ROS generation was estimated using H2DCF-DA and MitoSOX. Calcium transport was monitored by Calcium Green 5 N. NO synthesis activity was estimated using DAF-FM-DA. Brain acetylcholinesterase showed an in vivo IC20 of 0.30 μmol/L pyriproxyfen, and an IC50 of 92.5 μmol/L. The inhibitory effect on zbAChE activity was competitive-like. Respiratory control of Complex I/II decreased significantly after insecticide exposure. The MitoSOX test showed that O2- generation had a pyriproxyfen dose-dependent effect. Brain tissue lost 50% of Ca2+ uptake capacity at 0.1 μg/mL pyriproxyfen. Ca2+ release showed a clear mitochondrial impairment at lower pyriproxyfen exposures[1].

95737-68-1

C20H19NO3

321.37

S-31183;吡丙醚;Pyriproxyfen

DMSO:100 mg/mL (311.17 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years