Antitumor agent-68 是一种有效的微管蛋白抑制剂，具有良好的抗肿瘤活性，对宫颈癌细胞系 HeLa 和乳腺癌细胞系 MCF-7 细胞的IC50值分别为 3.6 和 3.8 μM。Antitumor agent-68 以剂量依赖的方式表现出良好的 ROS 和DPPH 自由基的清除活性。

Antitumor agent-68 is a potent tubulin inhibitor that exhibits good antitumor activity with IC 50 s of 3.6 and 3.8 μM for cervical cancer cells line HeLa and breast cancer cells line MCF-7 cells, respectively. Antitumor agent-68 demonstrates good scavenging activity of ROS and DPPH radical in a dose-dependent manner [1].

Antitumor agent-68 (Compound 7) shows anticancer activity with IC 50 s of 3.6 and 3.8 μM, for HeLa and MCF-7 cells, respectively [1]. Antitumor agent-68 (10 μΜ; 24 hours) leads to a 3-fold reduction of ROS production induced by Men in 3T3-L1 cells, and an EC 50 of 8.30 μg/mL for DPPH radical scavenging [1]. Cell Viability Assay [1] Cell Line: HeLa, MCF-7, 3T3-L1 Concentration: 10 μM Incubation Time: 24 hours Result: Showed anticancer activity by blocking the tubulin polymerization reaction. Reduced production of ROS, and scavenged DPPH radical.

2566497-96-7

C17H11NO2

261.27

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years