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MSI-1436
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MSI-1436图片
CAS NO:186139-09-3
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议

产品名称
Trodusquemine
Aminosterol-1436
产品介绍

产品描述

MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

体外活性

Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].

体内活性

Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].

Cas No.

186139-09-3

分子式

C37H72N4O5S

分子量

685.06

别名

Trodusquemine;Aminosterol-1436;MSI-1436

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years