MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].

Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].

1309370-86-2

C37H72N4O5S.7/2C3H6O3

1000.17

Trodusquemine lactate;Aminosterol-1436 lactate;MSI-1436 lactate

DMSO:54 mg/mL (53.99 mM),Need ultrasonic and warming
H2O:33.33 mg/mL (33.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years