Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity.

Squalamine lactate has a more general effect on the cell signaling cascade, which is common to VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

When administered intravitreally and therefore requires intravenous dosing, Squalamine is ineffective . However, systemic dosing has yielded promising results in rats as well as humans[2].

320725-47-1

C37H71N3O8S

718.04

MSI-1256F;Squalamine lactate

DMSO:36.66 mg/mL (51.06 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years