Amino-PEG11-amine 是一种基于 PEG（12 个单位）的 PROTAC 接头，能够结合两种基于单乙基雌酚的配体，是制备用于乳腺癌内分泌治疗的更具选择性和活性的 ER 拮抗剂的替代策略。

Amino-PEG11-amine is a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, providing an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

479200-82-3

C24H52N2O11

544.68

氨基-十二聚乙二醇-氨基;Amino-PEG11-amine

DMSO:10 mM
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In solvent: -80°C for 2 years