FLT3-IN-17 抑制CYPs和FLT3突变体的活性 (IC50s:<0.5 nM for D835Y)。FLT3-IN-17 也是一种FAK抑制剂，IC50值为 12 nM。FLT3-IN-17 可用于癌症研究。

FLT3-IN-17 inhibits CYPs and FLT3 mutants activity ( IC 50 s:<0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC 50 value of 12 nM. FLT3 ligand-2 can be used in the research of cancers [1].

FLT3-IN-17 (compound 25, 72 h) inhibits cell growth in HCT-116, MDA-MB-231, A375 cells [1]. FLT3-IN-17 (10 μM) inhibits cytochrome P450s (CYPs) with inhibition rates >55% [1]. FLT3-IN-17 inhibits FLT3 mutants activity (IC 50 s:<0.5 nM for D835Y, 1.6-183 nM for Ba/F3) [1]. Cell Proliferation Assay [1] Cell Line: HCT-116, MDA-MB-231, A375 cells Concentration: 0-1 μM approximately Incubation Time: 72 h Result: Inhibited cell growth with IC 50 values of 0.25, 0.46, 0.49 μM respectively.

2758999-62-9

C23H24N6O2S2

480.61

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years