FAK-IN-4 (Compound 7d) 是具有抗癌活性的潜在FAK抑制剂。FAK-IN-4 诱导细胞凋亡 (Apoptosis)。

FAK-IN-4 (Compound 7d) is potential FAK inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis [1].

FAK-IN-4 (Compound 7d) (0-200 μM, 72 h) shows antiproliferative activity against triple-negative breast cancer (TNBC) cells [1]. FAK-IN-4 (0-20 μM, 24 h) inhibits cell invasion and migration of MDA-MB-231 cells [1]. FAK-IN-4 (0-20 μM, 72 h) causes dose-dependent Y925 dephosphorylation of FAK, and induces apoptosis in MDA-MB-231 cells [1]. FAK-IN-4 inhibits the formation of focal adhesions (FAs) and stress fibers (SFs) in MDA-MB-231 cells [1]. Cell Proliferation Assay [1] Cell Line: MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A Concentration: 0.78, 1.56, 3.13, 5, 6.25, 100, 12.5, 25, 50, 100 and 200 μM Incubation Time: 72 h Result: Inhibited the growth of TNBC cells with IC 50 values of 8.37, 12.09, 9.07 and 40.63 μM against MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A cells. Cell Invasion Assay [1] Cell Line: MDA-MB-231 Concentration: 5, 10 and 20 μM Incubation Time: 24 h Result: Significantly inhibited the invasion of MDA-MB-231 cells in a dose-dependent manner. Western Blot Analysis [1] Cell Line: MDA-MB-231 Concentration: 5, 10 and 20 μM Incubation Time: 72 h Result: Caused an obvious dose-dependent Y925 dephosphorylation of FAK. Apoptosis Analysis [1] Cell Line: MDA-MB-231 Concentration: 5, 10 and 20 μM Incubation Time: 72 h Result: Increased the percentage of apoptotic MDA-MB-231 cells ranging from 13.10% to 41.59% in a dose-dependent manner.

C20H22N4O

334.41

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years