产品描述
T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria[1][2].
体外活性
PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL)[1].PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL[1].
体内活性
AK-599 (20 mg/kg; s.c. three times a day for 2 days) decreases the bacterial cell counts in lungs more than 99.9% in a mouse pneumonia model caused by MRSA[2].
Cas No.
189345-04-8
分子式
C22H20N8O5S4
分子量
604.71
别名
T-91825
储存和溶解度
DMSO:100 mg/mL (165.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years