(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel assay.

2123484-71-7

C24H37NO3

387.56

(±)10(11)-EDP Ethanolamide

Ethanol:PBS(pH 7.2) (1:1):0.5 mg/mL
DMSO:50 mg/mL
DMF:50 mg/mL
Ethanol:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years