Topoisomerase II inhibitor 11 (compound 3d) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂，其IC50为 2.89 μM。Topoisomerase II inhibitor 11 对肾癌 A498 细胞有 92.46% 的抑制作用，其IC50值为 3.5 μM。Topoisomerase II inhibitor 11 在 G2/M 期引起细胞周期阻滞，导致细胞增殖抑制和促凋亡活性。

Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC 50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC 50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity [1].

2476559-00-7

C27H21BrCl2N2O2S

588.34

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years