Anti-infective agent 4 (compound 73) 是一种具有口服活性的TrypaNOSoma cruzi抑制剂，IC50值为 0.016 μM。Anti-infective agent 4 可有效减少体内寄生虫负担。Anti-infective agent 4 可用于感染的研究。

Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC 50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection [1].

Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC 50 value of 0.016 μM [1]. Cell Cytotoxicity Assay [1] Cell Line: 3T3 cells Concentration: 0.1 nM-100 μM Incubation Time: 48 hours Result: Showed activity against 3T3 cells with an CC 50 value of ＞37 μM.

Anti-infective agent 4 (50 mg/kg; p.o. once daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model [1]. Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection [1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg once daily for five days Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.

2738381-52-5

C19H12F3N5O4

431.32

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years