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Methoctramine tetrahydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:104807-46-7
包装:5 mg
市场价:7000元

产品介绍

产品描述

Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor . Methoctramine tetrahydrochloride can inhibit Muscarine-induced bradycardia in vivo.

体外活性

Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner[1]. Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic nerve stimulation in the guinea-pig isolated, innervated tracheal tube preparation[2]. Methoctramine (≥10 μM) tetrahydrochloride reduces responses to both nerve stimulation and exogenous ACh[2].

体内活性

Methoctramine (300 μg/kg; i.v.) tetrahydrochloride strongly inhibits the Methacholine- and Muscarine-induced bradycardia in the anaesthetized rat, respectively[3].

Cas No.

104807-46-7

分子式

C36H63ClN4O2

分子量

619.38

别名

Methoctramine tetrahydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years