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7α-hydroxy-4-Cholesten-3-one
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7α-hydroxy-4-Cholesten-3-one图片
CAS NO:3862-25-7
包装:1 mg
市场价:7617元

产品介绍

产品描述

7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss and other diseases associated with defective bile acid biosynthesis.It is the physiological substrate for CYP8B1.

体外活性

7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids. The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by a 3β-hydroxysteroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one [1].

体内活性

7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm [2].

Cas No.

3862-25-7

分子式

C27H44O2

分子量

400.64

别名

7α-Hydroxy-4-cholesten-3-one

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years