产品描述
AT2 receptor agonist C21 is a druglike selective agonist of angiotensin II AT2 receptor(Ki of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively).
体内活性
AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat. Which induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats. And it lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1].
Cas No.
477775-14-7
分子式
C23H29N3O4S2
分子量
475.62
别名
AT2 receptor agonist C21
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years