Oxaprozin potassium 是一种口服有效的COX的抑制剂，其对人类血小板COX-1和 IL-1 刺激的人类滑膜细胞COX-2的IC50值分别为 2.2 和 36 μM。Oxaprozin potassium 还能抑制 NF-Κb 的活化。Oxaprozin potassium 诱导细胞凋亡 (Apoptosis)。Oxaprozin 具有抗炎活性。Oxaprozin potassium 介导的Akt/IKK/NF-Κb通路抑制有助于其抗炎特性。

Oxaprozin potassium is an orally active and potent COX inhibitor, with IC 50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties [1] [2].

Oxaprozin (0-100 μM) induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM). Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα [1]. Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation [2].

174064-08-5

C18H14KNO3

331.41

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years