19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.

191349-10-7

C30H37NO7

523.626

19,20-Epoxycytochalasin D

DMSO:Soluble
DMF:Soluble
Methanol:Soluble
Ethanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years