AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5

722543-50-2

C26H33Cl2FN7O6P

660.46

AZD 1152 (hydrochloride)

DMSO:PBS(pH 7.2) (1:4):0.2 mg/mL
DMSO:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years