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CV-159
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CV-159图片
CAS NO:86384-98-7
包装:5 mg
市场价:9850元

产品介绍

产品描述

CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.

体外活性

CV-159 (0.1-10 μM) obviously inhibits TNF-α (10 ng/ml, 24 h)-induced VCAM-1 in SMCs in a concentrationdependent manner. CV-159 (10 μM) inhibits TNF (24 h)-induced expression of e-selectin but not vascular cell adhesion molecule-1 and intercellular adhesion molecule-1.CV-159 (10 μM, 30 min) obviously inhibits the TNF-induced ROS production [1]. CV-159 inhibits TNF (20 min)-induced phosphorylation of JNK, p38, and NF-κB p65 (Ser536) [2].

体内活性

CV-159 decreases the size of the brain infarct after permanent middle cerebral artery (MCA) occlusion. CV-159 (5 and 10 mg/kg, p.o.) gives obviously protection against delayed neuronal death in the hippocampal CA1 region of the rats after 15-min transient forebrain ischemia. CV-159 obviously reduces the increase in the water content of the infarcted cortex induced by MCA occlusion [3].

Cas No.

86384-98-7

分子式

C31H34N4O7

分子量

574.62

别名

CV-159

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years