Waltonitone is a natural ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill.

In BEL-7402 cells,waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population . Waltonitone (25 μM; for 48 hours) induces BEL-7402 cells apoptosis. In BEL-7402 cells, Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 .

In male athymic mice (BALB/c nu/nu) in vivo, Waltonitone (i.v.; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth .

1252676-55-3

C30H48O2

440.7

Waltonitone

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years