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Pifithrin-βhydrobromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pifithrin-βhydrobromide图片
CAS NO:511296-88-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Cyclic PFT-α
Pifithrin-β
Cyclic Pifithrin-α hydrobromide
PFT-β
PFT β (hydrobromide)
Pifithrin-β hydrobromide
产品介绍
Pifithrin-β hydrobromide 是一种 p53 的抑制剂,可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。

产品描述

Pifithrin-β hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).

体外活性

PFTα molecule could not take a planar conformation required for AhR activation whereas PFTβ showed a conformation similar to those of the prototypical AhR ligand β-naphthoflavone. In both cell lines, PFTα and PFTβ provoked different responses related with AhR activation. However, when cyclization of PFTα to PFTβ was hampered by acetylation of the exocyclic nitrogen, all these responses were not observed. These results lead to the conclusion that the activation of the AhR is probably caused by PFTβ instead of PFTα.

Cas No.

511296-88-1

分子式

C16H17BrN2S

分子量

349.29

别名

Cyclic PFT-α;Pifithrin-β;Cyclic Pifithrin-α hydrobromide;PFT-β;PFT β (hydrobromide);Pifithrin-β hydrobromide

储存和溶解度

DMSO:26 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years