Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.

Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia, after binding to its receptor Gcgr. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis [1]. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes and that also increases phosphorylation of HNF4α [3].

Compared with PBS control, High-dose (1 mg/kg) Glucagon lowers glycemia and stimulates insulin secretion in ambient-fed mice. Low-dose (20 μg/kg) Glucagon enhances glycemia and does not stimulate insulin secretion in ambient-fed mice [4].

16941-32-5

C153H225N43O49S

3482.75

Porcine glucagon;胰高血糖素;Glucagon;Glucagon (1-29), bovine, human, porcine

DMSO:50 mg/mL (14.36 mM),Need ultrasonic
H2O:20 mg/mL (5.74 mM),ultrasonic and adjust pH to 2 with HCl
Powder: -20°C for 3 years
In solvent: -80°C for 2 years