Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].

ADC Linker

207613-14-7

C11H12N2O7

284.22

Mal-amido-(CH2COOH)2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years