Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTAC technology employs small molecules that recruit target proteins for ubiquitination and removal by the proteasome. The synthesis of PROTAC compounds that mediate the degradation of c-ABL and BCR-ABL by recruiting either Cereblon or Von Hippel Lindau E3 ligases is reported. Boc-C1-PEG2-C4-Cl is designated as 6-2-2[1].

1835705-53-7

C14H27ClO4

294.82

PROTAC Linker 1;Boc-C1-PEG2-C4-Cl

DMSO:50 mg/mL (169.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years