生物活性
Ro 31-8220 mesylate是一种PKC抑制剂，可抑制PKC激活剂佛波肉豆蔻酸酯乙酸酯（PMA，IC50 = 1.35 x 10（-6）M）或二酰基甘油（OAG，diC8）诱导的人PMN的刺激性液体胞吞作用
靶点信息
| PKCα | PKCβ2 | PKCβ1 | PKCε | PKCγ |
| 5 nM | 14 nM | 24 nM | 24 nM | 27 nM |
化学数据
| 目录号 | A13514 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 553.7 |
| Formula | C25H23N5O2SCH3SO3H |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 138489-18-6 |
| Synonyms | BIM IX, Bisindolylmaleimide IX (mesylate) |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O |
溶解度
| In vitro | DMSO | 85 mg/mL (153.52 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 18.06 mL | 90.3 mL | 180.6 mL |
| 0.5 mM | 3.61 mL | 18.06 mL | 36.12 mL |
| 1 mM | 1.81 mL | 9.03 mL | 18.06 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
*The above data is based on the productmolecular weight 553.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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