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Ro 31-8220 Mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ro 31-8220 Mesylate图片
CAS NO:138489-18-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品名称
BIM IX, Bisindolylmaleimide IX (mesylate)
产品介绍

生物活性

Ro 31-8220 mesylate是一种PKC抑制剂,可抑制PKC激活剂佛波肉豆蔻酸酯乙酸酯(PMA,IC50 = 1.35 x 10(-6)M)或二酰基甘油(OAG,diC8)诱导的人PMN的刺激性液体胞吞作用

靶点信息

PKCαPKCβ2PKCβ1PKCεPKCγ
5 nM14 nM24 nM24 nM27 nM

化学数据

目录号A13514
作用机制Inhibitor (抑制剂)
M. Wt553.7
FormulaC25H23N5O2SCH3SO3H
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.138489-18-6
SynonymsBIM IX, Bisindolylmaleimide IX (mesylate)
SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O

溶解度

In vitroDMSO85 mg/mL (153.52 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.06 mL90.3 mL180.6 mL
0.5 mM3.61 mL18.06 mL36.12 mL
1 mM1.81 mL9.03 mL18.06 mL
5 mM0.36 mL1.81 mL3.61 mL

*The above data is based on the productmolecular weight 553.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.