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P276-00
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
P276-00图片
CAS NO:920113-03-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
P276, P276-00
产品介绍

生物活性

P276-00是一种新型CDK1,CDK4和CDK9抑制剂,IC50分别为79 nM,63 nM和20 nM。在第2/3阶段。

Targets

TargetValue
CDK9/CyclinT1IC50: 20nM
CDK4/CyclinD1IC50: 63nM
CDK1/CyclinBIC50: 79nM
CDK2/CyclinAIC50: 224nM
CDK6/CyclinD3IC50: 396nM
CDK2/CyclinEIC50: 2.54μM
GSK-3βIC50: 2.771μM
CDK7/CyclinHIC50: 2.87μM
c-SrcIC50:<10μM
PKCαIC50: 10μM
MAPK1IC50: 22μM
PKCIC50: 25μM
MAPK2IC50: >100μM
PKAIC50: 575μM

化学数据

目录号A13547
作用机制Inhibitor (抑制剂)
M. Wt438.3
FormulaC21H20ClNO5.HCl
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.920113-03-7
SynonymsP276, P276-00
SMILESCN1CC[C@H]([C@@H]1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

溶解度

In vitro (25°C)DMSO79 mg/mL (180.24 mM)
Water79 mg/mL (180.24 mM)
Ethanol6 mg/mL (13.69 mM)
In vivo30% propylene glycol, 5% Tween 80, 65% D5W28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.82 mL114.08 mL228.15 mL
0.5 mM4.56 mL22.82 mL45.63 mL
1 mM2.28 mL11.41 mL22.82 mL
5 mM0.46 mL2.28 mL4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.