TH257 (TH-257; TH 257) is a novel and selective allosteric inhibitor of LIM kinases-LIMK1 and LIMK2 with important biological activity. It inhibits LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM.

纯度：≥98%

CAS：2244678-29-1