TP3011 (CH0793011) is a major active metabolite of CH-0793076 and is a highly potent topoisomerase I inhibitor equihighly potent as SN38. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro. References: [1]. Anthoney DA, et al. Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses.BMC Cancer. 2012 Nov 21;12:536. [2]. Niizuma S, et al. Synthesis of new camptothecin analogs with improved antitumor activities.Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21.

纯度：≥98%

CAS：534605-74-8