VU0134992 HCl is the first subtype-preferring, orally bioavailable and specific Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 HCl is 9-fold specific for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV. References: [1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.

纯度：≥98%

CAS：1052515-91-9