生物活性
SKQ1 prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices.SKQ1 reverses aging-related biomarkers in rats.SKQ1 slows down the development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats.SKQ1 increases the lifespan of male rodents under LP or SPF conditions.SKQ1 can penetrate cell membranes, and is proposed as an anti-aging treatment.Pretreatment of rats with mitochondria-targeted antioxidant SkQ1 (50 nmol/kg during 5 days) significantly increased the mRNA levels of Nrf2 transcription factor and Nrf2-induced genes encoding antioxidant enzymes SOD1, SOD2, CAT, and GPx4 in rat peripheral blood leukocytes. The increase in expression of these genes with SkQ1 addition was accompanied by increased activities of catalase, glutathione peroxidase, and glutathione-S-transferase in leukocytes.
化学数据
| 分子量 | 617.60 |
| 分子式 | C36H42BrO2P |
| CAS号 | 934826-68-3 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO 10 mM |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存
常温运输及临时存放 |
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6192 mL | 8.0959 mL | 16.1917 mL |
| 5 mM | 0.3238 mL | 1.6192 mL | 3.2383 mL |
| 10 mM | 0.1619 mL | 0.8096 mL | 1.6192 mL |
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