MS31 triHCl is a highly potent, high affinity and specific fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 triHCl highly potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 triHCl specificly binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 triHCl highly potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells. References: [1]. Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.

纯度：≥98%