V-9302 HCl is a competitive antagonist of transmembrane glutamine flux. V-9302 HCl specificly and highly potently targets the amino acid transporter ASCT2 (SLC1A5). V-9302 HCl inhibits ASCT2-mediated glutamine uptake (IC50=9.6 μM) in HEK-293 cells. References: [1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.

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