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Vps34 inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vps34 inhibitor 1图片
CAS NO:1383716-46-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件

Molecular Weight (MW)

391.47

Formula

C21H25N7O

CAS No.

1383716-46-8

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 78 mg/mL (199.2 mM)

Water: <1 mg/mL

Ethanol: <1 mg/mL

SMILES Code

CC(C)(O)CNC1=NC=C(C2=CC=NC(NC3=CC=NC(Cl)=C3)=N2)C(CC4CC4)=N1

Synonyms

Vps34-IN1, Compound 19, PIK-III analogue
实验参考方法

In Vitro

In vitro activity: VPS34 inhibitor 1 (Vps34-IN1, Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM. It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 induces a rapid dose-dependent dispersal of a specific PtdIns-(3)-P-binding probe from endosome membranes, within one minute, without affecting the ability of class I PI3K to regulate Akt.

In Vivo


Animal model


Formulation & Dosage


References

ACS Med Chem Lett. 2015 Nov 13;7(1):72-6.