您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > OG-L002
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
OG-L002
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OG-L002图片
CAS NO:1357302-64-7
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)225.29
FormulaC15H15NO
CAS No.1357302-64-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 45 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 45 mg/mL (199.7 mM)
Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 20 mg/mL
Synonyms

OGL002; OGL 002; OG-L002

Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol

InChi Key: DSOJSZXQRJGBCW-CABCVRRESA-N

InChi Code: InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m1/s1

SMILES Code: OC1=CC(C2=CC=C([C@@H]3[C@@H](N)C3)C=C2)=CC=C1

实验参考方法
In Vitro

In vitro activity: OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene


Kinase Assay: OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene


Cell Assay: HeLa or HFF cells are treated with the indicated concentrations of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended by the manufacturer and expressed as ratios to the cytotoxicity of the DMSO control.

In VivoOG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model.
Animal modelBALB/c female mice are infected with HSV-2 (strain MS).
Formulation & DosageDissolved in DMSO; 50 mg/kg; i.p.
References

Nature. 2012 Aug 16;488(7411):404; Trends Cell Biol. 2010 Nov;20(11):662-71.