OTS186935 triHCl is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 triHCl shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS186935 triHCl regulates the production of γ-H2AX in cancer cells. References: [1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.

纯度：≥98%

CAS：2093401-85-3