KY-05009 (KY05009) is a novel and potent ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor (Ki = 100 nM) with anti-cancer activity. KY-05009 inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. TNIK is involved in the interleukin-6-dependent proliferation of multiple myeloma cells and inhibition of Wnt signaling involving TNIK could be a therapeutic strategy for the treatment of interleukin-6-dependent multiple myeloma.

纯度：≥98%

CAS：1228280-29-2