曲美替尼二甲亚砜 (871700-17-3 ),(GSK-1120212 (DMSO solvate)是口服有效的MEK抑制剂，具备抑制MEK1和MEK2该 IC
50 分别为 2 nMTrametinib (DMSO solvate) 可以激活自噬 (autophagy)，诱导凋亡 (apoptosis)。
| 中文别名 | Trametinib (GSK1120212)(MSDS,871700-17-3) |
| CAS号 | 871700-17-3 |
| SMILES | Cc1c2c(c(n(c1=O)C)Nc3ccc(cc3F)I)c(=O)n(c(=O)n2c4cccc(c4)NC(=O)C)C5CC5 |
| Inchi | InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) |
| InchiKey | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
| 分子式 Formula | C26H23FIN5O4 |
| 分子量 Molecular Weight | 615.39 |
| Polarizability极化度 | 56.1±0.5 10-24cm3 |
| 密度 Density | 1.7±0.1 g/cm3 |
| 溶解度Solubility | Soluble in DMSO (100 mg/mL at 25 ℃), water (<1 mg/mL at 25 ℃), ethanol (<1 mg/mL at 25 ℃), and 30% PEG400/0.5% Tween80/5% propylene glycol (15 mg/ml). |
| 储藏条件 Storage conditions | 储存温度-20℃ |
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