MYCi361 (NUCC0196361) is a novel and potent MYC inhibitor (Kd = 3.2 μM) with potential anticancer activity, it demonstrated a narrow therapeutic index. MYCi361 engaged MYC inside cells, disrupted MYC/MAX dimers, and impaired MYC-driven gene expression. It also enhanced MYC phosphorylation on threonine-58, consequently increasing proteasome-mediated MYC degradation. MYCi361 was able to suppresses tumor growth and enhance anti-PD1 immunotherapy.

纯度：≥98%

CAS：2289690-31-7