GsMTx4, a TRPC1 and TRPC6 blocker, is a naturally occuring spider venom peptide composed of 34 amino acids, isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family. It selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology. GsMTx4 significantly attenuates bladder hyperactivity. Also blocks stretch-activated cation channels in astrocytes, cardiac cells, and smooth and skeletal muscle cells. Also inhibits TACAN, a mechanosensitive ion channel involved in the pain response.

纯度：≥98%

CAS：1209500-46-8