Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464,
INO-464), which is a novel, potent and orally bioavailable non-steroidal,
lyase-selective inhibitor of the steroid 17-alpha-hydroxylase/C17,20
lyase (CYP17A1 or CYP17, IC50=69 nM), with potential
anti-androgenic and antineoplastic activities. Upon administration,
CYP17 inhibitor VT-464 selectively inhibits the enzymatic activity of
the cytochrome P450 C17,20 lyase in both the testes and adrenal glands,
thereby inhibiting androgen production.
纯度：≥98%
CAS：1375603-36-3
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