Banoxantrone D12 dihydrochloride (AQ4N D12) is the deuterium labeled banoxantrone (AQ4N), which is a novel and potent bioreductive prodrug that can be reduced under hypoxia to a stable, DNA-affinic compound AQ4 (CAS#: 70476-63-0), which is a potent topoisomerase II inhibitor with antineoplastic activity. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. This results in an inhibition of DNA replication and repair in tumor cells. Combined with conventional therapeutic agents, both oxygenic and hypoxic regions of tumors can be targeted.

纯度：≥98%

CAS：1562067-05-3