Radicicol (Monorden), an antifungal antibiotic with antimalarial activity, is a potent Hsp90 N-terminal inhibitor with an IC50 value of 1 μM. It binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90
clients, leading to proteasomal degradation. Radicicol impairs mitochondrial replication
by targeting P. falciparum topoisomerase VIB.
纯度:≥98%
CAS:12772-57-5