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Dorsomorphin 2HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dorsomorphin 2HCl图片
CAS NO:1219168-18-9
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
Compound C, BML-275, BML275, BML 275
产品介绍

生物活性

Dorsomorphin 2HCl (BML-275)是BMP信号传导的选择性小分子抑制剂,可促进胚胎干细胞的心肌发生。Dorsomorphin通过抑制骨形态发生蛋白信号转导逆转乳腺癌起始细胞的间质表型。

靶点信息

AMPK (Cell-free assay)
109 nM(Ki)

化学数据

目录号A13720
作用机制Inhibitor (抑制剂)
M. Wt472.41
FormulaC24H27Cl2N5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1219168-18-9
SynonymsCompound C, BML-275, BML275, BML 275
SMILESC1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

溶解度

In vitro (25°C)DMSOInsoluble
Water87 mg/mL (184.15 mM)
EthanolInsoluble
In vivoPBS14 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.17 mL105.84 mL211.68 mL
0.5 mM4.23 mL21.17 mL42.34 mL
1 mM2.12 mL10.58 mL21.17 mL
5 mM0.42 mL2.12 mL4.23 mL

*The above data is based on the productmolecular weight 472.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.