Guanfacine is a potent, selective and centrally acting alpha-2
adrenergic agonist with antihypertensive activity and with Kd of 31 nM.
It displays 60-fold selectivity over α2B-adrenoceptors. Alpha-2 receptor
stimulation by guanfacine hydrochloride results in a decreased
sympathetic outflow from the vasomotor center to the heart, kidneys, and
peripheral vasculature. This leads to a decrease in heart rate and
peripheral vascular resistance.
纯度:≥98%
CAS:29110-47-2