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LSKL,Inhibitor of Thrombospondin TSP-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LSKL,Inhibitor of Thrombospondin TSP-1图片
CAS NO:283609-79-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

LSKL is a potent and peptide-based inhibitor of Thrombospondin TSP-1 with the potential to be used for treating hypertrophic scar. LSKL peptide was able to inhibit the overexpression of extracellular matrix and contractile ability of HTS (Hypertrophic scar) fibroblasts. In vivo, LSKL could attenuate the thickness of HTS, distortion of collagen alignment and fibrogenesis. Further, LSKL peptide not only remarkably attenuated cell proliferation and migration, but also induced cell apoptosis of HTS fibroblasts. In addition, LSKL peptide significantly suppressed the phosphorylation of PI3K, AKT, and mTOR, while not affecting the phosphorylation of Smad2/3 and MEK/ERK. LSKL might be a promising anti-fibrosis agent to HTS through modulating the PI3K/AKT/mTOR signaling pathway.

纯度:≥98%

CAS:283609-79-0