Ono 3403 is a synthetic serine protease inhibitor hat inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. orally bioavailable administration of the potent serine protease inhibitor ONO-3403 has an antitumor effect on malignant tumors suggested by the growth inhibition of mouse skin tumors in research. References: Tumurkhuu G, Koide N, Hiwasa T, Ookoshi M, Dagvadorj J, Abu Shadat Mohammod Noman, Iftakhar-E-Khuda I, Naiki Y, Komatsu T, Yoshida T, Yokochi T. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011 Feb;17(1):97-105. doi: 10.1177/1753425909353641. Epub 2009 Dec 18. PubMed PMID: 20023007. 2: Ohkoshi M, Okuda S. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002 Mar-Apr;22(2A):821-3. PubMed PMID: 12014657. 3: Hiwasa T, Kondo K, Nakagawara A, Ohkoshi M. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998 Apr 24;126(2):221-5. PubMed PMID: 9585070. 4: Ohkoshi M, Denda T, Hiwasa T. Growth-suppressive activities of serine protease inhibitors, FOY-305, ONO-3403 and FO-349 toward human carcinoma cells. Oncol Rep. 1997 May-Jun;4(3):521-3. PubMed PMID: 21590090. 5: Hiwasa T, Shimada H, Ochiai T, Liu TL, Yuasa Y, Takiguchi M, Ohkoshi M. Decrease in growth factor receptors after treatment with serine protease inhibitor ONO-3403. Int J Oncol. 2002 Apr;20(4):797-802. PubMed PMID: 11894127. 6: Ohkoshi M, Okuda S. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. Anticancer Res. 2001 May-Jun;21(3B):1803-8. PubMed PMID: 11497262. 7: Hiwasa T, Ohkoshi M. Growth-suppressive activities of serine protease inhibitors, ONO-3403 and ONO-5046, toward normal and transformed murine fibroblasts. Anticancer Res. 1996 Jul-Aug;16(4A):1823-6. PubMed PMID: 8712707.

纯度：≥98%

CAS：181586-07-2