RN1734 is a selective TRPV4 antagonist (IC50 are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). RN1734 exhibits selectivity for TRPV4 over other TRP channels (IC50 are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). It blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo. References: Feetham CH, Nunn N, Barrett-Jolley R. The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734. Front Pharmacol. 2015 Apr 23;6:83. doi: 10.3389/fphar.2015.00083. eCollection 2015. PubMed PMID: 25954200; PubMed Central PMCID: PMC4407506.

纯度：≥98%

CAS：946387-07-1