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Vandetanib hydrochloride(ZD-6474)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vandetanib hydrochloride(ZD-6474)图片
CAS NO:524722-52-9
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍

Vandetanib hydrochloride (formerly also known as ZD6474) is a novel, highly potent, orally bioavailable, selective inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. The inhibition of VEGFR-2 was 2.7-fold more potent than that of VEGFR-3 (Flt-4) kinase and 40-fold more potent than that of VEGFR-1. In human umbilical vein endothelial cells, treatment of ZD6474 resulted in significant inhibition of cell proliferation stimulated by VEGF and EGF with IC50 values of 60 and 170 nM, respectively.

纯度:≥98%

CAS:524722-52-9