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GNF 5837
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GNF 5837图片
CAS NO:1033769-28-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
GNF-5837, GNF5837
产品介绍

生物活性

GNF-5837是一种有效的,选择性的,口服可生物利用的pan-TRK抑制剂,可在源自表达TRKA和NGF的RIE细胞的小鼠异种移植模型中抑制肿瘤生长。

Targets

TargetValue
TrkCIC50: 7nM
TrkBIC50: 9nM
TrkAIC50: 11nM
PDGFRβIC50: 0.87μM
KitIC50: 0.91μM
JAK2IC50: 2.9μM
ALKIC50: 3.4μM
CSF-1RIC50: 4μM
FLT3IC50: 5.1μM
RETIC50: 5.3μM
MetIC50: 5.8μM
FGFR4IC50: 7μM
SrcIC50: 7.3μM
IGF-1RIC50: 7.6μM
Insulin ReceptorIC50: 8μM
AblIC50: 8.2μM
FGFR3IC50: 9.3μM

化学数据

目录号A13730
作用机制Inhibitor (抑制剂)
M. Wt535.49
FormulaC28H21F4N5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1033769-28-6
SynonymsGNF-5837, GNF5837
SMILESCC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4

溶解度

In vitroDMSO92 mg/mL (171.8 mM)
WaterInsoluble
EthanolWarmed: 8 mg/mL (14.93 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.67 mL93.37 mL186.74 mL
0.5 mM3.73 mL18.67 mL37.35 mL
1 mM1.87 mL9.34 mL18.67 mL
5 mM0.37 mL1.87 mL3.73 mL

*The above data is based on the productmolecular weight 535.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.