| CAS NO: | 62-97-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 389.51 |
|---|---|
| Formula | C20H24N.CH3O4S |
| CAS No. | 62-97-5; 15394-62-4 (cation) |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 25 mg/mL (64.2 mM) |
| Water: 28 mg/mL (71.9 mM) | |
| Ethanol: <1 mg/mL | |
| SMILES | [O-]S(=O)(OC)=O.C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)\C3=CC=CC=C3 |
| Synonyms | NSC41725; Diphemanil Methylsulfate; NSC 41725; NSC-41725; Prantal; Talpran; Chemical Name: 4-(diphenylmethylene)-1,1-dimethylpiperidin-1-ium methyl sulfate |
| In Vitro | In vitro activity: Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity. |
|---|---|
| In Vivo | The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%. |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Clin Pharmacol. 1992;42(6):689-91. |
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